March 31, 2025 | By Fred Palmer
Brand Inspiration: Exploring 12 Top-Selling Dietary Supplements on Amazon
In the ever-evolving world of nutraceuticals, staying ahead of the competition requires a keen understanding of market trends and consumer demands. Amazon, the world’s largest online marketplace, offers invaluable insights into what makes a product not only stand out but thrive in a crowded marketplace. For nutraceutical brand owners and entrepreneurs looking to make their mark in the dietary supplement space, studying the top sellers can offer key takeaways on product formulations, marketing strategies, and consumer engagement.
In this article, we dive deep into 12 top-selling dietary supplements on Amazon, highlighting the brands that have achieved significant success and the factors behind their booming sales. Whether you’re just starting or looking to scale your existing brand, these products provide a wealth of inspiration on what works in today’s competitive supplement landscape. Join us as we explore the top performers in the market and uncover the secrets to their success.
Based on current Amazon best-sellers in the dietary supplement capsule category, here are 12 popular options:
1) Physician’s Choice Probiotics 60 Billion CFU
What is it?: A high-potency probiotic supplement containing 10 probiotic strains and organic prebiotics, supporting digestive and immune health.
Delivery System: Capsules
Physician’s Choice 60 Billion Probiotic® is a dietary supplement formulated to support digestive and immune health. Each capsule contains 60 billion CFUs (colony-forming units) from 10 distinct probiotic strains, including:
- Lactobacillus
- Lactobacillus casei
- Lactobacillus paracasei
- Lactobacillus salivarius
- Lactobacillus plantarum
- Bifidobacterium lactis
- Bifidobacterium bifidum
- Bifidobacterium longum
- Bifidobacterium breve
- Lactobacillus bulgaricus
This blend is complemented by organic prebiotics such as Jerusalem artichoke root, acacia fiber, and chicory root, which nourish beneficial gut bacteria. The product’s delayed-release capsules are designed to withstand stomach acidity, ensuring the probiotics reach the intestines alive.
Physician’s Choice emphasizes transparency, guaranteeing that each serving contains 60 billion CFUs, as opposed to some brands that use terms like “equivalent to” without specifying viable counts. The supplement is free from common allergens, including soy, gluten, dairy, and artificial additives.
With over 5,500 reviews and a 4.8-star rating on Amazon, users frequently report improvements in digestion, regularity, and overall gut comfort. However, individual experiences may vary, and it’s advisable to consult with a healthcare professional before introducing new supplements into your routine.
Physician’s Choice 60 Billion Probiotic is a leading dietary supplement on Amazon, formulated to support digestive health, regularity, and overall wellness. While exact sales statistics are not publicly disclosed, several indicators highlight its prominence:
- Amazon’s Choice: The product is designated as “Amazon’s Choice” in the Probiotic Supplements category, reflecting high customer satisfaction and strong sales performance.
Customer Reviews: It has amassed over 70,000 verified five-star reviews on Amazon, underscoring its popularity and positive reception among consumers.
- Sales Revenue: According to a report by Bold Strategies, Physician’s Choice generated approximately $3.99 million in revenue from probiotic sales on Amazon, indicating significant market presence.
These factors collectively suggest that Physician’s Choice 60 Billion Probiotic is a best-selling and highly regarded product on Amazon.
Request A Quote
Green Star Labs can help if you are interested in developing a product similar to this formulation. Get in touch today and request a quote to get started.
Physician’s Choice 60 Billion Probiotic® is a registered trademark of Physician’s Choice and is not affiliated with Green Star Labs, Inc.
2) NatureWise® Vitamin D3 5000iu (125 mcg)
NatureWise® Vitamin D3 5000iu (125 mcg) is a dietary supplement designed to support various aspects of health, including bone strength, immune function, and muscle performance. Each softgel delivers 5,000 international units (IU) of vitamin D3 (cholecalciferol), which is the form naturally produced by the body in response to sunlight exposure.
Key Features:
- High Potency: Each softgel provides 5,000 IU (125 mcg) of vitamin D3, aligning with recommended daily intake levels for many individuals, especially those with vitamin D deficiency.
- Organic Olive Oil Base: The vitamin D3 is suspended in certified organic extra virgin olive oil, which may enhance absorption due to the oil’s healthy fat content.
- Purity and Quality: NatureWise emphasizes product purity, ensuring the supplement is free from artificial additives, gluten, soy, dairy, and is non-GMO.
- Bone and Muscle Support: Vitamin D3 plays a crucial role in calcium and phosphorus absorption, essential for maintaining strong bones and teeth, as well as supporting healthy muscle function.
Immune System Enhancement: Adequate vitamin D levels are vital for a well-functioning immune system, helping the body defend against common illnesses.
Customer Feedback:
Users have reported positive experiences with this supplement, noting improvements in overall well-being, energy levels, and mood. Many appreciate the high potency and the inclusion of organic olive oil, which may aid in vitamin D absorption. However, individual responses can vary, and it’s advisable to consult with a healthcare provider before starting any new supplement regimen.
Considerations:
- Sunlight Exposure: While supplementation can help maintain adequate vitamin D levels, sensible sun exposure also contributes to natural vitamin D synthesis.
- Dietary Sources: Incorporating vitamin D-rich foods, such as fatty fish, fortified dairy products, and egg yolks, can complement supplementation efforts.
- Consultation with Healthcare Provider: Before beginning any new supplement, especially at higher dosages like 5,000 IU daily, it’s important to discuss with a healthcare professional to ensure it’s appropriate for your individual health needs.
For more detailed information or to purchase NatureWise Vitamin D3 5000iu, you can visit their official website or trusted retailers such as Amazon and Walmart.
NatureWise Vitamin D3 5000iu is a leading dietary supplement on Amazon, recognized for supporting bone health, immune function, and muscle strength. While specific sales figures aren’t publicly available, several indicators highlight its prominence:
- Best Seller Ranking: The product consistently holds the #1 position in the Vitamin D Supplements category on Amazon, reflecting strong consumer demand.
- Customer Reviews: It has amassed over 178,000 customer reviews, maintaining an average rating of 4.7 out of 5 stars, indicating high customer satisfaction.
- Purchase Activity: The supplement is frequently purchased in bulk, with offerings such as a 360-count bottle providing a one-year supply, underscoring its popularity among consumers.
These factors collectively suggest that NatureWise Vitamin D3 5000iu is a best-selling and well-regarded product on Amazon.
Request A Quote
Green Star Labs can help if you are interested in developing a product similar to this formulation. Get in touch today and request a quote to get started.
NatureWise® is a registered trademark of NatureWise and is not affiliated with Green Star Labs, Inc.