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NMN (Nicotinamide Mononucleotide)

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Nicotinamide Mononucleotide (NMN) Capsule Manufacturing

In recent years, Nicotinamide Mononucleotide (NMN) has gained significant attention as a promising supplement for promoting longevity, improving energy metabolism, and supporting overall health. NMN is a precursor to Nicotinamide Adenine Dinucleotide (NAD⁺), a vital molecule involved in cellular energy production and DNA repair. As we age, NAD⁺ levels decline, leading to decreased cellular function and increased vulnerability to age-related diseases. NMN supplementation has been proposed as a way to restore NAD⁺ levels and enhance various aspects of health.

+ Supports Healthy Aging and Longevity*
+ Enhances Energy and Physical Performance*
+ Improves Cognitive Function*
+ Supports Cardiovascular Health*
+ Enhances Immune Function*
+ Boosts Metabolism and Weight Management*

Learn More about NMN…

*These statements have not been evaluated by the Food and Drug Administration. The products featured on this website are not intended to diagnose, treat, cure or prevent any disease.

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How NMN Works

NMN is a naturally occurring compound found in small amounts in foods like broccoli, avocados, and edamame. However, dietary sources do not provide sufficient NMN to significantly impact NAD⁺ levels. When supplemented, NMN is rapidly converted into NAD⁺ in the body, fueling essential biological processes such as:

Mitochondrial Function: NAD⁺ plays a crucial role in cellular energy production, ensuring that mitochondria operate efficiently.
DNA Repair: NAD⁺ activates sirtuins, a family of proteins that help repair DNA damage and regulate cellular health.
Metabolic Health: By enhancing NAD⁺ levels, NMN may improve insulin sensitivity and overall metabolic function.

Potential Health Benefits of NMN Supplementation

NMN supplementation holds great promise for promoting healthy aging, improving energy levels, and supporting metabolic and cognitive health. While preclinical and early human studies suggest significant benefits, more large-scale, long-term human trials are needed to confirm its full effects. As interest in longevity science continues to grow, NMN may play a key role in the future of health and wellness.

1. Supports Healthy Aging and Longevity

Several preclinical studies suggest that NMN may help slow the aging process. A study published in Cell Metabolism found that NMN supplementation in mice improved lifespan and overall health markers, including muscle function, insulin sensitivity, and mitochondrial activity (Yoshino et al., 2011).

A more recent human clinical trial conducted in 2021 showed that NMN supplementation effectively increased NAD⁺ levels in healthy middle-aged adults without significant adverse effects, suggesting its potential for promoting longevity (Irie et al., 2021).

2. Enhances Energy and Physical Performance

Mitochondrial dysfunction contributes to fatigue and reduced endurance with age. Research suggests NMN can improve muscle endurance and overall physical performance:

A 2022 randomized controlled trial (RCT) in humans found that NMN supplementation enhanced aerobic capacity and oxygen uptake in amateur runners (Huang et al., 2022).
Another study in aged mice showed that NMN improved mitochondrial function and exercise endurance by restoring NAD⁺ levels (Grozio et al., 2019).

3. Improves Cognitive Function and Neuroprotection

NAD⁺ is essential for brain function, and its decline is linked to neurodegenerative diseases. Preclinical studies suggest NMN can protect against cognitive decline:

A study published in Nature Aging showed that NMN supplementation enhanced cognitive function and reduced neuroinflammation in aged mice (Hou et al., 2018).
Human studies are limited but ongoing. A 2023 clinical trial is investigating NMN’s potential in improving cognitive function in older adults at risk for Alzheimer’s disease (ClinicalTrials.gov ID: NCT04910061).

4. Boosts Metabolism and Weight Management

Several studies indicate NMN may help regulate metabolism and reduce age-related weight gain:

A 2021 study in postmenopausal women found that NMN supplementation enhanced insulin sensitivity and improved glucose metabolism, suggesting benefits for metabolic health (Yoshino et al., 2021).
Animal studies have shown NMN reduces fat accumulation and improves lipid metabolism in obese mice (Mills et al., 2016).

5. Supports Cardiovascular Health

Cardiovascular disease is a leading cause of mortality, and NMN may improve vascular function:

A 2020 study in older men found that NMN supplementation improved vascular elasticity and endothelial function, both of which decline with age (de Picciotto et al., 2020).
NMN has been shown to increase blood vessel function and reduce inflammation in preclinical studies (Das et al., 2018).

6. Enhances Immune Function

NAD⁺ is critical for immune cell function, and NMN may help combat age-related immune decline:

Research published in Nature Immunology found that restoring NAD⁺ levels through NMN supplementation improved immune cell response in aging models (Minhas et al., 2019).
While human studies are limited, these findings suggest NMN may help support immune resilience against infections.

Custom Formulation Considerations

NMN is frequently combined with other complementary ingredients for enhanced benefits:

Resveratrol: A polyphenol that activates sirtuins, working synergistically with NMN to promote cellular health.
Pterostilbene: A compound similar to resveratrol, often paired with NMN for improved antioxidant effects.
CoQ10: To further support mitochondrial health.
Quercetin: Added to reduce senescent (aging) cells and boost overall efficacy.

NMN Safety and Considerations

NMN supplementation is generally considered safe, with no significant side effects reported in human studies. However, as with any supplement, it is important to:

Consult a healthcare professional before starting NMN, especially if you have underlying health conditions.
Choose high-quality NMN supplements from reputable manufacturers to ensure purity and efficacy.
Follow recommended dosages, as excessive intake may not provide additional benefits

Green Star Labs Equipment and Capabilites

Gummies

Gummy Full-Scale Starchless Manufacturing

Pectin Based – Vegan, Sugar and Sugar-Free custom formulations
Standard 4.5g Squares and Custom Molds
Multiple production lines – 100,000 to 500,000 Pieces per Shift @ 4.5g
Examples: Lion’s Mane/Cordyceps Focus Gummies, Melatonin-less Sleep Gummies, CBD Relax and Revive Gummies, Apple Cider Vinegar Gut Health Gummies, Ashwagandha Adaptogen Gummies, Sugar-Free Creatine Gummy

Small-Scale Gummy R&D

Testing the Market, Developing Flavor Profiles, Troubleshooting and problem solving product challenges.
Examples: Developing SOP and Formulations for Creatine Gummies, Flavor Masking Caffeine and Cannabinoids

Gummy Co-Packing

5 – 150ct Pouches Packaged in-line – Up to 14,000 pouches per shift @ 5ct .
20 – 90ct Bottles Packaged in-line – Up to 8000 bottles per shift @ 30ct .
Examples: 5 and 20ct Snoop Pouches, 30ct Top Fungi Jars, 60ct Fndmntl ACV Jars, 120ct Novos Pouches.

Capsules & Tablets

Capsule Full-Scale Starchless Manufacturing

Tooling for Size 1, 0, 00 shells (HPMC Standard)
Multiple Encapsulators – 60,000 to 1.1M per shift
Examples: NAD+ Precursor Supplements, Joint Health, Curcumin and Herbal Blends

Small-Scale Capsule R&D

Piloting and Running Trials for efficacy or product performance

Tablet Full-Scale Manufacturing

Tooling for 10mm, 14mm, 16mm, 26mm Diameter Punches
24 Station Press – up to 900,000 per shift
Examples: Probiotic Tablets, Chewable herbal remedies, Calcium and mineral blends